Mechanistic Target of Rapamycin, but Not the Integrated Stress Response, Promotes ATF4-Dependent Metabolic Reprogramming in TGF-β-Treated Lung Fibroblasts

E. O'Leary, Y. Tian, A. Meliton, R. Niğdelioğlu, P. S. Woods, L. Kimmig, K. Sun, G. Gökalp, R. Cetin-Atalay, R. Guzy, G. Mutlu, R. Hamanaka

2020

TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.

E. O'Leary, Yufeng Tian, R. Niğdelioğlu, L. Witt, R. Cetin-Atalay, A. Meliton, P. S. Woods, L. Kimmig, K. Sun, G. Gökalp, G. Mutlu, R. Hamanaka

American journal of respiratory cell and molecular biology, 2020

Endogenous Itaconate Is Not Required for Particulate Matter-Induced Inflammatory Response in Macrophages

K. Sun, A. Meliton, P. S. Woods, L. Kimmig, E. O'Leary, Y. Tian, G. Gokalp, R. Hamanaka, G. Mutlu

2020

Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.

P. S. Woods, L. Kimmig, A. Meliton, K. Sun, Yufeng Tian, E. O'Leary, G. Gökalp, R. Hamanaka, G. Mutlu

American journal of respiratory cell and molecular biology, 2020

Glutamine Metabolism Supports Collagen Protein Synthesis in Human Lung Fibroblasts

E. O'Leary, R. Hamanaka, L. Witt, R. Niğdelioğlu, Y. Tian, A. Meliton, P. S. Woods, K. Sun, L. Kimmig, D. Wu, G. Gokalp, N. O. Dulin, G. Mutlu

C62. FIBROBLAST BIOLOGY, 2019

Particulate Matter Induces the Expression of Aconitate Decarboxylase 1, Which by Its Metabolite Itaconate Attenuates Inflammatory Response in Macrophages

K. Sun, A. Meliton, P. S. Woods, L. Kimmig, E. O'Leary, D. Wu, Y. Tian, R. Hamanaka, G. Mutlu

D26. HEALTH EFFECTS ASSOCIATED WITH INDOOR AND OUTDOOR AIR POLLUTION, 2019

Stimulation of the Na+/K+-ATPase Leads to a Differential Response in Bone Marrow-Derived Macrophages

L. Kimmig, P. S. Woods, K. Sun, E. O'Leary, A. Meliton, Y. Tian, R. Hamanaka, G. Mutlu

D107. MITOCHONDRIA AND ER STRESS IN HOMEOSTASIS AND REPAIR, 2019

De Novo Proline Synthesis Promotes Collagen Production in Human Lung Fibroblasts

R. Hamanaka, E. O'Leary, L. Witt, R. Niğdelioğlu, Y. Tian, A. Meliton, P. S. Woods, K. Sun, L. Kimmig, G. Gokalp, D. Wu, N. O. Dulin, G. Mutlu

C62. FIBROBLAST BIOLOGY, 2019

Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts.

R. Hamanaka, E. O'Leary, L. Witt, Yufeng Tian, G. Gökalp, A. Meliton, N. Dulin, G. Mutlu

American journal of respiratory cell and molecular biology, 2019

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin‐induced Pulmonary Fibrosis

R. Hamanaka, R. Niğdelioğlu, A. Meliton, Yufeng Tian, L. Witt, E. O'Leary, K. Sun, P. S. Woods, David Wu, B. Ansbro, S. Ard, J. M. Rohde, N. Dulin, R. Guzy, G. Mutlu

American journal of respiratory cell and molecular biology, 2017

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production*

R. Niğdelioğlu, R. Hamanaka, A. Meliton, E. O'Leary, L. Witt, Takugo Cho, Kai Sun, C. Bonham, David Wu, P. S. Woods, A. Husain, Donald Wolfgeher, N. Dulin, N. Chandel, G. Mutlu

The Journal of Biological Chemistry, 2016